Visualizing Regional Myocardial Blood Flow in the Mouse
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چکیده
منابع مشابه
Visualizing regional myocardial blood flow in the mouse.
RATIONALE The spatial distribution of blood flow in the hearts of genetically modified mice is a phenotype of interest because derangements in blood flow may precede detectable changes in organ function. However, quantifying the regional distribution of blood flow within organs of mice is challenging because of the small organ volume and the high resolution required to observe spatial differenc...
متن کاملRegional Myocardial Blood Flow
Do oxygen-derived free radicals, generated at the time of reperfusion, lethally injure viable, previously ischemic myocardium, damage vascular endothelium, and impair recovery of postischemic contractile function? To address these issues, 23 anesthetized open-chest dogs underwent 2 hours of left anterior descending coronary artery occlusion followed by 4 hours of reperfusion. Immediately prior ...
متن کاملRegional Myocardial Blood Flow
nary artery disease has provided an intense stimulus for expansion of our present knowledge of the coronary circulation. In the experimental animal laboratory, the electromagnetic flowmeter has proved to be an excellent tool by which one can study dynamic aspects of the coronary circulation. A flowmeter is clearly unsuitable for human investigation; therefore, the search for a simple method of ...
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sion. Arch Intern Med 133: 916-929, 1974 34. Bohr DF: Angiotensin on vascular smooth muscle. In Angiotensin, edited by IH Page, FM Bumpus. New York, Springer-Verlag, 1974, pp424-428 35. Williams GH, HollenbergNK, Braley LM: Influence of sodium intake on vascular and adrenal angiotensin II receptors. Endocrinology 98: 1343-1350, 1976 36. Fray FCS, Johnson MD, Barger AC: Renin release and pressor...
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Using H,15O (half-life = 2.1 min) we demonstrated that a modification of the tissue autoradiographic approach permitted quantitation of myocardial blood flow in open-chest dogs by direct assay of myocardial tissue and that noninvasive estimation with positron-emission tomography (PET) delineated relative myocardial blood flow in intact dogs. ln open-chest anesthetized dogs, the single-pass extr...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.113.301162